Fascinating! I’m curious how you think about the path dependence in this process. Surely the first 1000 sequences were a tiny sampling of the fitness landscape. Yet, those results probably helped design the next library (2100 variants) and so forth. Had you started with a different set of 1000 sequences in Round 0, how close would you have been to solution you ended up with?
Fascinating! I’m curious how you think about the path dependence in this process. Surely the first 1000 sequences were a tiny sampling of the fitness landscape. Yet, those results probably helped design the next library (2100 variants) and so forth. Had you started with a different set of 1000 sequences in Round 0, how close would you have been to solution you ended up with?
Thanks for sharing these!